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"Large scale human brain connectivity study from intracortical stimulations" Olivier David (Video)
Mini-course
Human behaviour and cognition are linked to brain dynamics, which complexity starts to being reproduced by whole brain models in silico. These models are in desperate need of experimental data in human documenting spatial and temporal properties of large-scale connectivity that would allow to finesse and validate them. The only type of data for this purpose are the electrophysiological responses recorded during direct electrical stimulations (DES) of cortical regions performed in patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes.
The first part of the course will be centered on the main results of the previous ERC project (Functional Brain Tractography, F-TRACT, f-tract.eu). In this project, we have created an international clinical consortium to gather these rare data and have developed the largest DES database. We have published several versions of the functional tractography F-TRACT atlas, which provides new information on the directionality, latency and velocity of neural signals in human. Those neuronal parameters are estimated from neural mass models inverted on the data. Beyond standard parcel-based neuroanatomical atlases, we are now working on the first functional atlas of large white matter tracts. Preliminary results will be presented. This work is now being integrated to the European Flagship Human Brain Project centered on information communication technologies for brain sciences.
The second part of the course will be about how the same concept of cortical excitability as inferred from DES in intracranial recordings be studied in healthy subjects or non-implanted patients using neuronavigated and robotized transcranial magnetic stimulation coupled with electroencephalography (TMS/EEG).
Olivier David graduated in applied physics at Ecole Normale Supérieure de Cachan, and obtained a PhD from Université Paris Sud in signal processing applied to human neurophysiology at CNRS / La Salpêtrière Hospital. He is now Director of Research at INSERM and leads a research group in Grenoble focused on preclinical and clinical neurophysiology in refractory neurological and psychiatric disorders. The main topic of his current research is to understand the effects of brain stimulation on the organization of functional brain networks. He has published more than 100 articles in international peer-reviewed journals, which have received about 5000 citations. He has participated in about 60 competitive research grants, and is currently Deputy Leader of the Medical Informatics Platform of the European Flagship Human Brain Project. He has been involved as scientist in 16 clinical trials, and as expert in many national and international evaluation committees.
Video 1 Video 2 Video 3 Video 4
The second part of the course will be about how the same concept of cortical excitability as inferred from DES in intracranial recordings be studied in healthy subjects or non-implanted patients using neuronavigated and robotized transcranial magnetic stimulation coupled with electroencephalography (TMS/EEG).
Olivier David graduated in applied physics at Ecole Normale Supérieure de Cachan, and obtained a PhD from Université Paris Sud in signal processing applied to human neurophysiology at CNRS / La Salpêtrière Hospital. He is now Director of Research at INSERM and leads a research group in Grenoble focused on preclinical and clinical neurophysiology in refractory neurological and psychiatric disorders. The main topic of his current research is to understand the effects of brain stimulation on the organization of functional brain networks. He has published more than 100 articles in international peer-reviewed journals, which have received about 5000 citations. He has participated in about 60 competitive research grants, and is currently Deputy Leader of the Medical Informatics Platform of the European Flagship Human Brain Project. He has been involved as scientist in 16 clinical trials, and as expert in many national and international evaluation committees.
Video 1 Video 2 Video 3 Video 4
Dates
Created on January 9, 2020